Based on our dysautonomia research, we have identified ME/CFS syndrome as a classic condition due to autonomic imbalance. There is recent reporting on a commonality between ME/CFS and post COVID syndrome. We have identified specific abnormalities, similar to ME/CFS patients with post COVID syndrome, using the ANS and CS-100 testing modalities. Integrative treatment approaches based on autonomic modulation that we have successfully implemented in ME/CFS patients have been utilized to optimize post COVID syndrome management.